Andrea Kleine is the author of the novels, CALF, a Publishers' Weekly Best Fiction Book of 2015; and EDEN, named one of "Summer's Smartest and Most Innovative Thrillers" by Vanity Fair and a finalist for a Publishing Triangle Award in LGBTQ fiction. Her work includes fiction, essays, performances, and, most recently, films. She is a five-time MacDowell fellow and a New York Foundation for the Arts fellow.

Her essays have been published in The Paris Review, PAJ: a journal of performance and art, BOMB, Electric Literature, LitHub, Lenny Letter, and The Los Angeles Review of Books.

Her critically acclaimed performance works have been presented extensively since the 1990s, and for which she has received numerous commissions, grants, and awards. Her recent evening-length performance works have been commissioned by The Chocolate Factory Theater and New York Live Arts.

She has been described as an "enigmatic and eccentric" (The New York Times), "brainy, allusive Downtown artist" (The Village Voice), whose work is "wry, poignant" (The New York Times), "something like genius" (ArtVoice), and “fiercely engages with the complexities of the cruelty we impose on each other as individuals and as a society” (Bomb).

Her feature film, THE END IS NOT WHAT I THOUGHT IT WOULD BE, created in isolation during the pandemic, premiered in 2022, and is streaming now.